' 
SCIENTIFIC SCORE
Possibly Effective
Based on 9 Researches
7.7
USERS' SCORE
Good
Based on 4 Reviews
8.6
Supplement Facts
Serving Size: 1 vegan softgel
Amount Per Serving
%DV
Calories
5
_
Total Fat
0.5 g
<1%‡
Microalgae Oil (40% DHA)which typically provides:
500 mg
*
DHA (Docosahexaenoic Acid) [Ω-3]
200 mg
*
Top Medical Research Studies
9
Fish oil improves knee function
Efficacy and Safety of Fish Oil in Treatment of Knee Osteoarthritis.
Highly relevant to knee osteoarthritis
We explored how fish oil, rich in docosahexaenoic acid (DHA), can impact knee pain, particularly for those suffering from osteoarthritis. In our study, we involved 75 participants, divided into three groups, each taking either 1,000 mg or 2,000 mg of fish oil daily for eight weeks. We carefully measured their knee pain and walking abilities before and after the supplementation.
The results were encouraging. Those who took fish oil reported notable improvements in knee performance and function compared to a control group. On a satisfaction scale, the average score was an impressive 9.06 out of 10! While most participants experienced the benefits of fish oil without complications, there was one case of hematuria that was unrelated to the treatment.
Overall, our findings suggest that taking 1,000 to 2,000 mg of fish oil daily can significantly enhance knee performance and is safe for individuals with mild to moderate knee osteoarthritis. However, it’s worth noting that increasing the dose beyond 1,000 mg didn't yield greater benefits.
The results were encouraging. Those who took fish oil reported notable improvements in knee performance and function compared to a control group. On a satisfaction scale, the average score was an impressive 9.06 out of 10! While most participants experienced the benefits of fish oil without complications, there was one case of hematuria that was unrelated to the treatment.
Overall, our findings suggest that taking 1,000 to 2,000 mg of fish oil daily can significantly enhance knee performance and is safe for individuals with mild to moderate knee osteoarthritis. However, it’s worth noting that increasing the dose beyond 1,000 mg didn't yield greater benefits.
Read More
9
DHA alleviates knee arthritis pain
Chronic oral or intraarticular administration of docosahexaenoic acid reduces nociception and knee edema and improves functional outcomes in a mouse model of Complete Freund's Adjuvant-induced knee arthritis.
Study directly assesses DHA's effect
We explored the impacts of docosahexaenoic acid (DHA), a type of omega-3 fatty acid, on knee pain and inflammation in a mouse model of knee arthritis. Our objective was to see if DHA could ease spontaneous pain, reduce swelling, and improve mobility in mice that had been induced with arthritis using Complete Freund's Adjuvant (CFA).
Starting fifteen days after the initial injections, we administered oral DHA in various dosages daily, as well as intraarticular DHA twice a week. We then looked at how these treatments affected spontaneous pain-related behaviors, such as flinching in the injured leg, alongside measurements of knee swelling and overall activity levels. We also investigated whether DHA's effects involved the body's opioid receptors by introducing naloxone, an opioid antagonist.
The results were promising: our findings indicate that DHA significantly reduced pain and inflammation, contributing to improved mobility in the mice. This marks a noteworthy advancement, as it highlights the potential of DHA in managing joint pain and inflammation, particularly in conditions like rheumatoid arthritis. Overall, we suggest that DHA treatment could be a valuable option for those suffering from painful arthritic symptoms.
Starting fifteen days after the initial injections, we administered oral DHA in various dosages daily, as well as intraarticular DHA twice a week. We then looked at how these treatments affected spontaneous pain-related behaviors, such as flinching in the injured leg, alongside measurements of knee swelling and overall activity levels. We also investigated whether DHA's effects involved the body's opioid receptors by introducing naloxone, an opioid antagonist.
The results were promising: our findings indicate that DHA significantly reduced pain and inflammation, contributing to improved mobility in the mice. This marks a noteworthy advancement, as it highlights the potential of DHA in managing joint pain and inflammation, particularly in conditions like rheumatoid arthritis. Overall, we suggest that DHA treatment could be a valuable option for those suffering from painful arthritic symptoms.
Read More
7
17-HDHA linked to knee pain relief
Association of the resolvin precursor 17-HDHA, but not D- or E- series resolvins, with heat pain sensitivity and osteoarthritis pain in humans.
High relevance to knee pain study
We set out to investigate how a compound called 17-HDHA, a precursor to docosahexaenoic acid (DHA), influences knee pain in people suffering from osteoarthritis. Our research involved two groups: healthy volunteers and individuals with knee osteoarthritis.
We measured levels of 17-HDHA and several other resolvins in participants and assessed their heat pain sensitivity as well as their knee pain. Interestingly, we found that higher levels of 17-HDHA were linked to increased heat pain thresholds, meaning individuals felt less pain when exposed to heat. Moreover, knee osteoarthritis patients with higher levels of 17-HDHA reported lower pain scores, suggesting a potential analgesic effect.
However, it's important to note that the other resolvins tested, including D-series and E-series resolvins, did not show a significant association with either heat pain sensitivity or osteoarthritis pain. Additionally, the effects of 17-HDHA appeared to be independent of DHA levels in the body. This suggests that 17-HDHA itself may play a crucial role in managing knee pain in osteoarthritis patients.
We measured levels of 17-HDHA and several other resolvins in participants and assessed their heat pain sensitivity as well as their knee pain. Interestingly, we found that higher levels of 17-HDHA were linked to increased heat pain thresholds, meaning individuals felt less pain when exposed to heat. Moreover, knee osteoarthritis patients with higher levels of 17-HDHA reported lower pain scores, suggesting a potential analgesic effect.
However, it's important to note that the other resolvins tested, including D-series and E-series resolvins, did not show a significant association with either heat pain sensitivity or osteoarthritis pain. Additionally, the effects of 17-HDHA appeared to be independent of DHA levels in the body. This suggests that 17-HDHA itself may play a crucial role in managing knee pain in osteoarthritis patients.
Read More
Most Useful Reviews
9.5
Vegan supplement benefits
This supplement is fantastic for my knee pain. I need to take a DHA/EPA supplement regularly to avoid the pain, and I appreciate that this one is vegan sourced with quality ingredients.
Read More
8.8
Reduced arthritis pain
DEVA vegan omega 3 is an excellent product. As a sceptic, I'm not easily influenced by placebos, yet I have found it alleviates some arthritis symptoms in my fingers and knees. The price is fantastic, and I’ve had great service from iHerb.
Read More
8.8
Effective vegan alternative
I take these supplements for knee pain, and they seem to help. I'm pleased to have found a vegan alternative to omega 3s that fits my needs.
Read More
Medical Researches
SCIENTIFIC SCORE
Possibly Effective
Based on 9 Researches
7.7
9
Omega-3 improves knee pain relief
Efficacy of Extract and/or an Omega-3-Based Product for Improving Pain and Function in People Older Than 40 Years with Persistent Knee Pain: A Randomized Double-Blind Controlled Clinical Trial.
Significant pain reduction observed
We conducted a compelling study to investigate how docosahexaenoic acid (DHA), often found in omega-3 supplements, influences knee pain in individuals aged 40 and older. The research was carefully designed as a randomized, double-blind, controlled clinical trial with four groups over an 8-week period. The participants dealt with persistent knee discomfort, scoring more than 3 on a visual analog scale for pain.
Among the groups, some received DHA alongside an omega-3 product called AvailOm, while others were given the omega-3 product alone or a placebo. Notably, those consuming the combined treatment of DHA and AvailOm showed improvements in both quality of life and muscle strength. There was a significant reduction in pain levels for participants taking AvailOm compared to those on placebo, particularly noticeable by the eighth week.
The study findings suggested that the omega-3 product effectively reduced pain perception and enhanced physical functionalities, including better performance on the Up and Go test. While the overall increase in omega-3 fatty acids was encouraging, the specific contributions of DHA to these improvements remain ambiguous due to the lack of isolation of DHA's effects in the results.
Overall, our study presents promising evidence that omega-3 supplementation can provide relief from knee pain and enhance quality of life in older adults suffering from this condition, though the unique role of DHA warrants further exploration.
Among the groups, some received DHA alongside an omega-3 product called AvailOm, while others were given the omega-3 product alone or a placebo. Notably, those consuming the combined treatment of DHA and AvailOm showed improvements in both quality of life and muscle strength. There was a significant reduction in pain levels for participants taking AvailOm compared to those on placebo, particularly noticeable by the eighth week.
The study findings suggested that the omega-3 product effectively reduced pain perception and enhanced physical functionalities, including better performance on the Up and Go test. While the overall increase in omega-3 fatty acids was encouraging, the specific contributions of DHA to these improvements remain ambiguous due to the lack of isolation of DHA's effects in the results.
Overall, our study presents promising evidence that omega-3 supplementation can provide relief from knee pain and enhance quality of life in older adults suffering from this condition, though the unique role of DHA warrants further exploration.
Read More
9
Fish oil improves knee function
Efficacy and Safety of Fish Oil in Treatment of Knee Osteoarthritis.
Highly relevant to knee osteoarthritis
We explored how fish oil, rich in docosahexaenoic acid (DHA), can impact knee pain, particularly for those suffering from osteoarthritis. In our study, we involved 75 participants, divided into three groups, each taking either 1,000 mg or 2,000 mg of fish oil daily for eight weeks. We carefully measured their knee pain and walking abilities before and after the supplementation.
The results were encouraging. Those who took fish oil reported notable improvements in knee performance and function compared to a control group. On a satisfaction scale, the average score was an impressive 9.06 out of 10! While most participants experienced the benefits of fish oil without complications, there was one case of hematuria that was unrelated to the treatment.
Overall, our findings suggest that taking 1,000 to 2,000 mg of fish oil daily can significantly enhance knee performance and is safe for individuals with mild to moderate knee osteoarthritis. However, it’s worth noting that increasing the dose beyond 1,000 mg didn't yield greater benefits.
The results were encouraging. Those who took fish oil reported notable improvements in knee performance and function compared to a control group. On a satisfaction scale, the average score was an impressive 9.06 out of 10! While most participants experienced the benefits of fish oil without complications, there was one case of hematuria that was unrelated to the treatment.
Overall, our findings suggest that taking 1,000 to 2,000 mg of fish oil daily can significantly enhance knee performance and is safe for individuals with mild to moderate knee osteoarthritis. However, it’s worth noting that increasing the dose beyond 1,000 mg didn't yield greater benefits.
Read More
9
DHA alleviates knee arthritis pain
Chronic oral or intraarticular administration of docosahexaenoic acid reduces nociception and knee edema and improves functional outcomes in a mouse model of Complete Freund's Adjuvant-induced knee arthritis.
Study directly assesses DHA's effect
We explored the impacts of docosahexaenoic acid (DHA), a type of omega-3 fatty acid, on knee pain and inflammation in a mouse model of knee arthritis. Our objective was to see if DHA could ease spontaneous pain, reduce swelling, and improve mobility in mice that had been induced with arthritis using Complete Freund's Adjuvant (CFA).
Starting fifteen days after the initial injections, we administered oral DHA in various dosages daily, as well as intraarticular DHA twice a week. We then looked at how these treatments affected spontaneous pain-related behaviors, such as flinching in the injured leg, alongside measurements of knee swelling and overall activity levels. We also investigated whether DHA's effects involved the body's opioid receptors by introducing naloxone, an opioid antagonist.
The results were promising: our findings indicate that DHA significantly reduced pain and inflammation, contributing to improved mobility in the mice. This marks a noteworthy advancement, as it highlights the potential of DHA in managing joint pain and inflammation, particularly in conditions like rheumatoid arthritis. Overall, we suggest that DHA treatment could be a valuable option for those suffering from painful arthritic symptoms.
Starting fifteen days after the initial injections, we administered oral DHA in various dosages daily, as well as intraarticular DHA twice a week. We then looked at how these treatments affected spontaneous pain-related behaviors, such as flinching in the injured leg, alongside measurements of knee swelling and overall activity levels. We also investigated whether DHA's effects involved the body's opioid receptors by introducing naloxone, an opioid antagonist.
The results were promising: our findings indicate that DHA significantly reduced pain and inflammation, contributing to improved mobility in the mice. This marks a noteworthy advancement, as it highlights the potential of DHA in managing joint pain and inflammation, particularly in conditions like rheumatoid arthritis. Overall, we suggest that DHA treatment could be a valuable option for those suffering from painful arthritic symptoms.
Read More
8
Docosahexaenoic acid reduces knee pain
Omega-3-carboxylic acids provide efficacious anti-inflammatory activity in models of crystal-mediated inflammation.
Study compares omega-3 and indomethacin
We explored the anti-inflammatory effects of docosahexaenoic acid, a type of omega-3 fatty acid, in treating knee pain linked to crystal-induced inflammation. In this study, human cells and rat models were used to assess how well docosahexaenoic acid could mitigate pain and swelling caused by various inflammatory crystals.
Our findings revealed that acute treatment with docosahexaenoic acid notably reduced the production of interleukin-1β, an inflammatory marker. In animal models, we observed a dose-dependent decrease in pain and swelling after administering docosahexaenoic acid alongside a control treatment, indomethacin. Specifically, docosahexaenoic acid helped ease pain by 23%, while indomethacin reduced pain by 41%.
Although both treatments showed promise, the study also highlighted that the overall effectiveness of docosahexaenoic acid could be affected by other components in complex formulations. Nevertheless, these results suggest that omega-3 fatty acids could be beneficial for conditions like crystal arthritis and potentially other inflammatory diseases mediated by interleukin-1β.
Our findings revealed that acute treatment with docosahexaenoic acid notably reduced the production of interleukin-1β, an inflammatory marker. In animal models, we observed a dose-dependent decrease in pain and swelling after administering docosahexaenoic acid alongside a control treatment, indomethacin. Specifically, docosahexaenoic acid helped ease pain by 23%, while indomethacin reduced pain by 41%.
Although both treatments showed promise, the study also highlighted that the overall effectiveness of docosahexaenoic acid could be affected by other components in complex formulations. Nevertheless, these results suggest that omega-3 fatty acids could be beneficial for conditions like crystal arthritis and potentially other inflammatory diseases mediated by interleukin-1β.
Read More
8
Investigating DHA's effects on OA pain
Targeting the D Series Resolvin Receptor System for the Treatment of Osteoarthritis Pain.
Relevant but lacks specificity
Our investigation aimed to understand how docosahexaenoic acid (DHA), particularly through its connection to resolvin pathways, may help ease knee pain in individuals with osteoarthritis (OA). Using joint tissue samples from OA patients, we looked closely at two resolvin receptors and their correlation with pain-related markers in the body.
We employed two animal models of OA to assess the effects of DHA's precursor, 17(R)-hydroxy-docosahexaenoic acid (17[R]-HDoHE). This involved measuring changes in pain behaviors, joint health, and key inflammatory markers in the spinal cord. Notably, we observed that treatment with 17[R]-HDoHE could reverse established pain behaviors, leading to significant increases in plasma levels of resolvin D2 and a decrease in spinal inflammation.
However, it’s crucial to highlight that while there were positive outcomes in pain relief, the treatment did not affect the underlying joint pathology. Our research underscores a central mechanism through which the D series resolvin pathways can impact pain in OA, providing insights into new therapeutic strategies for managing this debilitating condition.
We employed two animal models of OA to assess the effects of DHA's precursor, 17(R)-hydroxy-docosahexaenoic acid (17[R]-HDoHE). This involved measuring changes in pain behaviors, joint health, and key inflammatory markers in the spinal cord. Notably, we observed that treatment with 17[R]-HDoHE could reverse established pain behaviors, leading to significant increases in plasma levels of resolvin D2 and a decrease in spinal inflammation.
However, it’s crucial to highlight that while there were positive outcomes in pain relief, the treatment did not affect the underlying joint pathology. Our research underscores a central mechanism through which the D series resolvin pathways can impact pain in OA, providing insights into new therapeutic strategies for managing this debilitating condition.
Read More
User Reviews
USERS' SCORE
Good
Based on 4 Reviews
8.6
9.5
Vegan supplement benefits
This supplement is fantastic for my knee pain. I need to take a DHA/EPA supplement regularly to avoid the pain, and I appreciate that this one is vegan sourced with quality ingredients.
8.8
Reduced arthritis pain
DEVA vegan omega 3 is an excellent product. As a sceptic, I'm not easily influenced by placebos, yet I have found it alleviates some arthritis symptoms in my fingers and knees. The price is fantastic, and I’ve had great service from iHerb.
8.8
Helps joint pain
I really like this product. I believe it helps alleviate pain in my joints, particularly with knee pain.
8.8
Effective vegan alternative
I take these supplements for knee pain, and they seem to help. I'm pleased to have found a vegan alternative to omega 3s that fits my needs.
