5/9/2025
Last update
5/9/2025
Reviewed By
Reviewed By
Overview
SCIENTIFIC SCORE
Possibly Effective
Based on 17 Researches
7.3
USERS' SCORE
Good
Based on 4 Reviews
8.3
Supplement Facts
Serving Size: 1 vegan softgel
Amount Per Serving
%DV
Calories
5
_
Total Fat
0.5 g
<1%‡
Microalgae Oil (40% DHA)which typically provides:
500 mg
*
DHA (Docosahexaenoic Acid) [Ω-3]
200 mg
*
Top Medical Research Studies
We explored whether purified docosahexaenoic acid (DHA), an omega-3 fatty acid, can ease knee pain and swelling in a mouse model of arthritis. Mice with arthritis were treated with either oral or injected DHA, and we observed notable improvements in pain behavior and knee swelling.
This study highlights that DHA may reduce pain and inflammation in knee arthritis, suggesting it could be a helpful option for those suffering from rheumatoid arthritis. However, it’s essential to keep in mind that these results come from an animal model, and human studies are necessary.
This study highlights that DHA may reduce pain and inflammation in knee arthritis, suggesting it could be a helpful option for those suffering from rheumatoid arthritis. However, it’s essential to keep in mind that these results come from an animal model, and human studies are necessary.
Read More
8
Omega-3 reduces knee pain effectively
We conducted a rigorous clinical trial to investigate how omega-3 fish oil affects knee pain in people aged 40 and older. In this double-blind study with four groups, we found that those taking an omega-3-based product, AvailOm, experienced a notable reduction in pain intensity compared to a placebo.
By week eight, participants reported less discomfort and improved quality of life. Additionally, the intake of AvailOm led to better muscle strength and sleep quality, making it a promising option for alleviating persistent knee pain. Overall, omega-3 fish oil shows effective benefits for older adults struggling with knee pain.
By week eight, participants reported less discomfort and improved quality of life. Additionally, the intake of AvailOm led to better muscle strength and sleep quality, making it a promising option for alleviating persistent knee pain. Overall, omega-3 fish oil shows effective benefits for older adults struggling with knee pain.
Read More
8
Fish oil improves knee function
We explored the effects of omega-3 fish oil on knee osteoarthritis by evaluating 75 participants over 8 weeks. Divided into three groups, they took either 1,000 mg or 2,000 mg of fish oil each day.
Our findings showed that both dosages improved knee function and pain relief compared to a control group. However, the higher dose of 2,000 mg did not provide additional benefits over the 1,000 mg dose. Overall, participants reported high satisfaction with their results, and the treatment was deemed safe with minimal side effects.
Our findings showed that both dosages improved knee function and pain relief compared to a control group. However, the higher dose of 2,000 mg did not provide additional benefits over the 1,000 mg dose. Overall, participants reported high satisfaction with their results, and the treatment was deemed safe with minimal side effects.
Read More
Most Useful Reviews
9
Vegan supplement benefits
This supplement is fantastic for my knee pain. I need to take a DHA/EPA supplement regularly to avoid the pain, and I appreciate that this one is vegan sourced with quality ingredients.
Read More
7.5
Reduced arthritis pain
4 people found this helpful
DEVA vegan omega 3 is an excellent product. As a sceptic, I'm not easily influenced by placebos, yet I have found it alleviates some arthritis symptoms in my fingers and knees. The price is fantastic, and I’ve had great service from iHerb.
Read More
7.5
Effective vegan alternative
I take these supplements for knee pain, and they seem to help. I'm pleased to have found a vegan alternative to omega 3s that fits my needs.
Read More
Medical Researches
SCIENTIFIC SCORE
Possibly Effective
Based on 17 Researches
7.3
- All Researches
9.5
Phytalgic promotes knee pain relief
We evaluated the effectiveness of Phytalgic, a supplement containing fish oil, on reducing knee pain in patients with osteoarthritis. In a randomized double-blind study of 81 participants, those taking Phytalgic reported lower usage of analgesics and NSAIDs compared to the placebo group.
Our findings showed significant reductions in pain, stiffness, and overall knee function, highlighting the potential benefit of Phytalgic in managing osteoarthritis symptoms. Overall, it seems that Phytalgic may offer an alternative relief option for those suffering from knee pain.
Our findings showed significant reductions in pain, stiffness, and overall knee function, highlighting the potential benefit of Phytalgic in managing osteoarthritis symptoms. Overall, it seems that Phytalgic may offer an alternative relief option for those suffering from knee pain.
Read More
We explored whether purified docosahexaenoic acid (DHA), an omega-3 fatty acid, can ease knee pain and swelling in a mouse model of arthritis. Mice with arthritis were treated with either oral or injected DHA, and we observed notable improvements in pain behavior and knee swelling.
This study highlights that DHA may reduce pain and inflammation in knee arthritis, suggesting it could be a helpful option for those suffering from rheumatoid arthritis. However, it’s essential to keep in mind that these results come from an animal model, and human studies are necessary.
This study highlights that DHA may reduce pain and inflammation in knee arthritis, suggesting it could be a helpful option for those suffering from rheumatoid arthritis. However, it’s essential to keep in mind that these results come from an animal model, and human studies are necessary.
Read More
8
Omega-3 reduces knee pain effectively
We conducted a rigorous clinical trial to investigate how omega-3 fish oil affects knee pain in people aged 40 and older. In this double-blind study with four groups, we found that those taking an omega-3-based product, AvailOm, experienced a notable reduction in pain intensity compared to a placebo.
By week eight, participants reported less discomfort and improved quality of life. Additionally, the intake of AvailOm led to better muscle strength and sleep quality, making it a promising option for alleviating persistent knee pain. Overall, omega-3 fish oil shows effective benefits for older adults struggling with knee pain.
By week eight, participants reported less discomfort and improved quality of life. Additionally, the intake of AvailOm led to better muscle strength and sleep quality, making it a promising option for alleviating persistent knee pain. Overall, omega-3 fish oil shows effective benefits for older adults struggling with knee pain.
Read More
8
We investigated how the green-lipped mussel (GLM) can help in managing knee pain caused by osteoarthritis (OA). In our study using a rat model, we induced OA and then administered GLM to see its effects on pain and cartilage health.
Results showed that GLM significantly improved pain levels while protecting against cartilage damage and inflammation. It also reduced markers associated with destructive processes in the joints.
This suggests that GLM could be a beneficial treatment option for those suffering from OA and associated knee pain.
Results showed that GLM significantly improved pain levels while protecting against cartilage damage and inflammation. It also reduced markers associated with destructive processes in the joints.
This suggests that GLM could be a beneficial treatment option for those suffering from OA and associated knee pain.
Read More
8
This study focused on whether l-serine and EPA could help relieve chronic knee and low-back pain. We learned that 120 adults participated in a randomized, double-blind, placebo-controlled trial. They received either the active treatment or a placebo over an 8-week period.
After analyzing results, we found that l-serine and EPA significantly reduced pain scores. This suggests that these two substances may effectively alleviate discomfort for those suffering from persistent knee pain.
After analyzing results, we found that l-serine and EPA significantly reduced pain scores. This suggests that these two substances may effectively alleviate discomfort for those suffering from persistent knee pain.
Read More
User Reviews
USERS' SCORE
Good
Based on 4 Reviews
8.3
- All Reviews
- Positive Reviews
- Negative Reviews
9
Vegan supplement benefits
This supplement is fantastic for my knee pain. I need to take a DHA/EPA supplement regularly to avoid the pain, and I appreciate that this one is vegan sourced with quality ingredients.
Read More
7.5
Reduced arthritis pain
4 people found this helpful
DEVA vegan omega 3 is an excellent product. As a sceptic, I'm not easily influenced by placebos, yet I have found it alleviates some arthritis symptoms in my fingers and knees. The price is fantastic, and I’ve had great service from iHerb.
Read More
7.5
Effective vegan alternative
I take these supplements for knee pain, and they seem to help. I'm pleased to have found a vegan alternative to omega 3s that fits my needs.
Read More
7.5
Helps joint pain
I really like this product. I believe it helps alleviate pain in my joints, particularly with knee pain.
Read More
Frequently Asked Questions
7.5
Reduced arthritis pain
4 people found this helpful
DEVA vegan omega 3 is an excellent product. As a sceptic, I'm not easily influenced by placebos, yet I have found it alleviates some arthritis symptoms in my fingers and knees. The price is fantastic, and I’ve had great service from iHerb.
9
Vegan supplement benefits
This supplement is fantastic for my knee pain. I need to take a DHA/EPA supplement regularly to avoid the pain, and I appreciate that this one is vegan sourced with quality ingredients.
7.5
Effective vegan alternative
I take these supplements for knee pain, and they seem to help. I'm pleased to have found a vegan alternative to omega 3s that fits my needs.
7.5
Helps joint pain
I really like this product. I believe it helps alleviate pain in my joints, particularly with knee pain.
8
Omega-3 reduces knee pain effectively
We conducted a rigorous clinical trial to investigate how omega-3 fish oil affects knee pain in people aged 40 and older. In this double-blind study with four groups, we found that those taking an omega-3-based product, AvailOm, experienced a notable reduction in pain intensity compared to a placebo.
By week eight, participants reported less discomfort and improved quality of life. Additionally, the intake of AvailOm led to better muscle strength and sleep quality, making it a promising option for alleviating persistent knee pain. Overall, omega-3 fish oil shows effective benefits for older adults struggling with knee pain.
By week eight, participants reported less discomfort and improved quality of life. Additionally, the intake of AvailOm led to better muscle strength and sleep quality, making it a promising option for alleviating persistent knee pain. Overall, omega-3 fish oil shows effective benefits for older adults struggling with knee pain.
8
Fish oil improves knee function
We explored the effects of omega-3 fish oil on knee osteoarthritis by evaluating 75 participants over 8 weeks. Divided into three groups, they took either 1,000 mg or 2,000 mg of fish oil each day.
Our findings showed that both dosages improved knee function and pain relief compared to a control group. However, the higher dose of 2,000 mg did not provide additional benefits over the 1,000 mg dose. Overall, participants reported high satisfaction with their results, and the treatment was deemed safe with minimal side effects.
Our findings showed that both dosages improved knee function and pain relief compared to a control group. However, the higher dose of 2,000 mg did not provide additional benefits over the 1,000 mg dose. Overall, participants reported high satisfaction with their results, and the treatment was deemed safe with minimal side effects.
We investigated whether krill oil could help reduce knee pain in adults experiencing mild to moderate osteoarthritis. Over six months, participants took either krill oil or a placebo in a well-structured double-blind trial.
While the results showed that krill oil was safe and led to some modest improvements in knee pain, stiffness, and physical function, the overall benefits were limited.
Thus, while krill oil may serve as a mild alternative for osteoarthritis pain relief, it’s essential to manage expectations regarding its effectiveness.
While the results showed that krill oil was safe and led to some modest improvements in knee pain, stiffness, and physical function, the overall benefits were limited.
Thus, while krill oil may serve as a mild alternative for osteoarthritis pain relief, it’s essential to manage expectations regarding its effectiveness.
8
We investigated how the green-lipped mussel (GLM) can help in managing knee pain caused by osteoarthritis (OA). In our study using a rat model, we induced OA and then administered GLM to see its effects on pain and cartilage health.
Results showed that GLM significantly improved pain levels while protecting against cartilage damage and inflammation. It also reduced markers associated with destructive processes in the joints.
This suggests that GLM could be a beneficial treatment option for those suffering from OA and associated knee pain.
Results showed that GLM significantly improved pain levels while protecting against cartilage damage and inflammation. It also reduced markers associated with destructive processes in the joints.
This suggests that GLM could be a beneficial treatment option for those suffering from OA and associated knee pain.
3
We examined whether high-dose fish oil could better relieve knee osteoarthritis symptoms than a low dose. In a thorough trial involving 202 participants, they were divided into groups receiving either high-dose (4.5 g omega-3) or low-dose fish oil (0.45 g omega-3) for up to two years.
While both groups experienced some improvement in knee pain and function, the low-dose group responded better overall. There was no significant difference in cartilage loss or other health outcomes, leading us to conclude that higher doses may not be more effective and warrant further research into alternative oil blends.
While both groups experienced some improvement in knee pain and function, the low-dose group responded better overall. There was no significant difference in cartilage loss or other health outcomes, leading us to conclude that higher doses may not be more effective and warrant further research into alternative oil blends.
References
- Pérez-Piñero S, Muñoz-Carrillo JC, Victoria-Montesinos D, García-Muñoz AM, Andreu-Caravaca L, et al. Efficacy of Extract and/or an Omega-3-Based Product for Improving Pain and Function in People Older Than 40 Years with Persistent Knee Pain: A Randomized Double-Blind Controlled Clinical Trial. Nutrients. 2023;15. 10.3390/nu15173848
- Stonehouse W, Benassi-Evans B, Bednarz J, Vincent AD, Hall S, et al. Krill oil improved osteoarthritic knee pain in adults with mild to moderate knee osteoarthritis: a 6-month multicenter, randomized, double-blind, placebo-controlled trial. Am J Clin Nutr. 2022;116:672. 10.1093/ajcn/nqac125
- Jhun J, Na HS, Cho KH, Kim J, Moon YM, et al. A green-lipped mussel reduces pain behavior and chondrocyte inflammation and attenuated experimental osteoarthritis progression. PLoS One. 2021;16:e0259130. 10.1371/journal.pone.0259130
- VanDusseldorp TA, Escobar KA, Johnson KE, Stratton MT, Moriarty T, et al. Impact of Varying Dosages of Fish Oil on Recovery and Soreness Following Eccentric Exercise. Nutrients. 2020;12. 10.3390/nu12082246
- Sasahara I, Yamamoto A, Takeshita M, Suga Y, Suzuki K, et al. l-Serine and EPA Relieve Chronic Low-Back and Knee Pain in Adults: A Randomized, Double-Blind, Placebo-Controlled Trial. J Nutr. 2020;150:2278. 10.1093/jn/nxaa156
- Valdes AM, Ravipati S, Menni C, Abhishek A, Metrustry S, et al. Association of the resolvin precursor 17-HDHA, but not D- or E- series resolvins, with heat pain sensitivity and osteoarthritis pain in humans. Sci Rep. 2017;7:10748. 10.1038/s41598-017-09516-3
- Sibille KT, King C, Garrett TJ, Glover TL, Zhang H, et al. Omega-6: Omega-3 PUFA Ratio, Pain, Functioning, and Distress in Adults With Knee Pain. Clin J Pain. 2018;34:182. 10.1097/AJP.0000000000000517
- Peanpadungrat P. Efficacy and Safety of Fish Oil in Treatment of Knee Osteoarthritis. J Med Assoc Thai. 2015;98 Suppl 3:S110.
- Hill CL, March LM, Aitken D, Lester SE, Battersby R, et al. Fish oil in knee osteoarthritis: a randomised clinical trial of low dose versus high dose. Ann Rheum Dis. 2016;75:23. 10.1136/annrheumdis-2014-207169
- Torres-Guzman AM, Morado-Urbina CE, Alvarado-Vazquez PA, Acosta-Gonzalez RI, Chávez-Piña AE, et al. Chronic oral or intraarticular administration of docosahexaenoic acid reduces nociception and knee edema and improves functional outcomes in a mouse model of Complete Freund's Adjuvant-induced knee arthritis. Arthritis Res Ther. 2014;16:R64. 10.1186/ar4502
- Jacquet A, Girodet PO, Pariente A, Forest K, Mallet L, et al. Phytalgic, a food supplement, vs placebo in patients with osteoarthritis of the knee or hip: a randomised double-blind placebo-controlled clinical trial. Arthritis Res Ther. 2009;11:R192. 10.1186/ar2891
- Tartibian B, Maleki BH, Abbasi A. The effects of ingestion of omega-3 fatty acids on perceived pain and external symptoms of delayed onset muscle soreness in untrained men. Clin J Sport Med. 2009;19:115. 10.1097/JSM.0b013e31819b51b3
- Kubo Y, Ikeya M, Sugiyama S, Takachu R, Tanaka M, et al. Effects of n-3 polyunsaturated fatty acid supplementation on quadriceps weakness immediately after total knee arthroplasty: a pilot, randomized, open-label clinical trial. J Phys Ther Sci. 2023;35:93. 10.1589/jpts.35.93
- Iverson C, Bacong A, Liu S, Baumgartner S, Lundström T, et al. Omega-3-carboxylic acids provide efficacious anti-inflammatory activity in models of crystal-mediated inflammation. Sci Rep. 2018;8:1217. 10.1038/s41598-018-19252-x
- Huang J, Burston JJ, Li L, Ashraf S, Mapp PI, et al. Targeting the D Series Resolvin Receptor System for the Treatment of Osteoarthritis Pain. Arthritis Rheumatol. 2017;69:996. 10.1002/art.40001
- Barden AE, Moghaddami M, Mas E, Phillips M, Cleland LG, et al. Specialised pro-resolving mediators of inflammation in inflammatory arthritis. Prostaglandins Leukot Essent Fatty Acids. 2016;107:24. 10.1016/j.plefa.2016.03.004
- Gruenwald J, Petzold E, Busch R, Petzold HP, Graubaum HJ. Effect of glucosamine sulfate with or without omega-3 fatty acids in patients with osteoarthritis. Adv Ther. 2009;26:858. 10.1007/s12325-009-0060-3
